<scp>PFOA</scp> Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

; Pdx-1-Cre (KC) mouse model of pancreatic cancer, we report upregulation of lipid species within the acylcarnitine (CAR) and ceramide (Cer) lipid groups and downregulation of lipids in the phosphatidylcholine, phosphatidylethanolamine (PE), and phosphatidylserine groups following exposure to 1 and 5 ppm PFOA for 6 months. The most upregulated lipids following PFOA exposure included individual Cer and CAR species while PE species comprised the top group of downregulated lipids. Thromboxane B2 (TXB2), a proinflammatory eicosanoid, was the most upregulated lipid in the 1 and 5 ppm KC treatment groups with a fold-change of ~12-fold and ~31-fold in the 1 and 5 ppm KC treatment groups, respectively. As these lipid alterations have been linked to mitochondrial dysfunction, obesity, and inflammation, our results suggest that PFOA-induced lipid alterations may be involved in adverse health outcomes including diabetes and pancreatic cancer.