A NOTCH2 pathogenic variant alters the osteoblast and vascular cell transcriptome of mouse femurs
cells implying decreased transcription of genes constituting these clusters. In conclusion, a novel NOTCH2 deleterious variant associated with skeletal fragility alters the osteogenic and vascular transcriptome in femurs from adult mice.
Authors
- Ernesto Canalis (ORCID: https://orcid.org/0000-0002-9154-952X)
- Lauren Schilling
- Emily Denker
Institutions
- UConn Health (US)
Publication Details
- Journal
- Bone
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1016/j.bone.2026.117909
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases