Molecular Analysis of Biliary Tract Neoplasms Associated with Familial Adenomatous Polyposis
Objectives: Familial adenomatous polyposis (FAP) is an inherited disorder characterized by multiple colorectal polyposis and is frequently associated with a variety of extracolonic lesions. However, neoplastic lesions of the biliary tract system, excluding those of the ampulla of Vater, are extremely rare in FAP, and the impact of APC alterations on their tumorigenesis remains unclear. We aimed to clarify the relationship between germline variants and somatic variants in the APC gene in biliary tract neoplasms (BTNs) of FAP patients.
Authors
- Takehiro Shiraishi (ORCID: https://orcid.org/0000-0001-9150-2679)
- Toshiro Ogura (ORCID: https://orcid.org/0000-0002-2711-6076)
- Hidetaka Eguchi (ORCID: https://orcid.org/0000-0002-0300-3587)
- Noriko Tanabe (ORCID: https://orcid.org/0000-0002-8240-007X)
- Noriyasu Chika
- Ibuki Fujinuma
- Yasushi Okazaki (ORCID: https://orcid.org/0000-0003-3241-5502)
- Hideyuki Ishida
- Yoshiko Mori
- Tetsuji Takayama
- Tatsuro Yamaguchi
- Takatoshi Matsuyama
Institutions
- Tokyo Metropolitan Komagome Hospital (JP)
- Juntendo University (JP)
- Saitama Cancer Center (JP)
- Social Insurance Saitama Chuo Hospital (JP)
- Saitama Medical University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Journal of the Anus Rectum and Colon
- Published
- 2026-04-24
- DOI
- https://doi.org/10.23922/jarc.2025-117
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00