A macrophage MHC-I axis links intratumoral heterogeneity to terminal CD8+ T cell exhaustion in lung adenocarcinoma
. We also derived a six-gene decision-tree classifier (CDC45, CENPF, PCLAF, SCGB3A1, CDCA8, and NDC80) predicting ITH/TEX phenotypes. These data support a macrophage MHC-I axis linking ITH to terminal TEX and motivate combining checkpoint blockade with macrophage reprogramming or modulation of antigen-processing and presentation.
Authors
- P. Zhang (ORCID: https://orcid.org/0000-0002-9177-6108)
- Qiang Li (ORCID: https://orcid.org/0009-0007-4804-9830)
- Jianping Lu
- Pengyu Nan
- Weihao Kong
- Liqiang Wang
- Haiyan Gao
- Shangzhen Yin
- Yurou Guo
- Mengrui Wang
- Hongmei Shen
Institutions
- Harbin Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1038/s41698-026-01446-6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Heilongjiang Provincial Postdoctoral Science Foundation