Morphological control of gut lumen access shapes enteroendocrine cell function
In this issue, Yu et al. (https://doi.org/10.1083/jcb.202506084) uncover a genetic mechanism that determines whether enteroendocrine cells access the gut lumen. Their findings link regional transcriptional control to epithelial integration of enteroendocrine cells, revealing how cell morphology shapes nutrient sensing in the intestinal epithelium.
Authors
- Qingyin Qian (ORCID: https://orcid.org/0009-0001-2634-1423)
- Ryusuke Niwa (ORCID: https://orcid.org/0000-0002-1716-455X)
- Yu-ichiro Nakajima (ORCID: https://orcid.org/0000-0002-1823-5989)
Institutions
- University of Tsukuba (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1083/jcb.202603173
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Science and Technology Corporation
- Japan Society for the Promotion of Science
- Fusion Oriented REsearch for disruptive Science and Technology