Novel Genetic Risk Loci for Pancreatic Ductal Adenocarcinoma Identified in a Genome-wide Study of African Ancestry Individuals
), a locus previously associated with PDAC. Known loci at 5p15.33, 7q32.3, 8q24.21 and 7q25.1 also replicated (P value <0.01). Multi-ancestral fine-mapping identified two potential causal SNPs (rs3830069 and rs2735940) at 5p15.33. Collectively these findings identified novel PDAC risk loci and expanded our understanding of this deadly cancer in underrepresented populations, emphasizing the multifactorial nature of PDAC risk including inherited genetic and non-genetic factors. Statement of Significance: To understand how genetic variation contributes to PDAC risk in Black people in North American, we studied individuals of genetically-inferred African ancestry. We identified novel risk loci and differences in the contribution of known loci. This demonstrates that ancestry-informed genetic analyses improve our understanding of PDAC risk and enhances discovery.
Authors
- Phyllis J. Goodman (ORCID: https://orcid.org/0000-0001-9660-7074)
- Geoffrey S. Tobias (ORCID: https://orcid.org/0000-0002-2878-8253)
- Federico Canzian (ORCID: https://orcid.org/0000-0002-4261-4583)
- Howard D. Sesso (ORCID: https://orcid.org/0000-0002-9698-9954)
- Jean Wactawski‐Wende (ORCID: https://orcid.org/0000-0003-3096-9595)
- Samuel O. Antwi (ORCID: https://orcid.org/0000-0003-2372-9489)
- Katelyn E. Connelly (ORCID: https://orcid.org/0000-0002-1693-5519)
- Alan A. Arslan (ORCID: https://orcid.org/0000-0002-7775-8085)
- Alison Patricia Klein (ORCID: https://orcid.org/0000-0003-2737-8399)
- Fay Kastrinos (ORCID: https://orcid.org/0000-0003-2518-0100)
- Yu Chen (ORCID: https://orcid.org/0000-0001-7856-4648)
- William R. Bamlet (ORCID: https://orcid.org/0000-0003-2903-1284)
- Núria Malats (ORCID: https://orcid.org/0000-0003-2538-3784)
- Miquel Porta
- Laufey T. Ámundadóttir (ORCID: https://orcid.org/0000-0003-1859-8971)
- Xie Shu
- Brian M. Wolpin (ORCID: https://orcid.org/0000-0002-0455-1032)
- Rayjean J. Hung (ORCID: https://orcid.org/0000-0002-4486-7496)
- Paul Scheet (ORCID: https://orcid.org/0000-0002-5173-7497)
- I Lee
- Irene Orlow (ORCID: https://orcid.org/0000-0001-6234-6961)
- Ann L. Oberg (ORCID: https://orcid.org/0000-0003-2539-9807)
- Zhanmo Ni (ORCID: https://orcid.org/0009-0006-9636-0482)
- Herbert Yu (ORCID: https://orcid.org/0000-0003-3950-4815)
- Rachael Z. Stolzenberg‐Solomon (ORCID: https://orcid.org/0000-0003-3698-7006)
- Silverman Debra
- Rachel Ε. Neale (ORCID: https://orcid.org/0000-0001-7162-0854)
- Candelaria Vergara (ORCID: https://orcid.org/0000-0003-3297-8057)
- Kari G. Rabe (ORCID: https://orcid.org/0000-0002-7313-1875)
- Shannon M. Lynch (ORCID: https://orcid.org/0000-0002-2066-9620)
- Priya Duggal (ORCID: https://orcid.org/0000-0001-5809-2081)
- Margaret A. Park
- Gabriella Andreotti (ORCID: https://orcid.org/0000-0002-1096-3324)
- Amy Hutchinson (ORCID: https://orcid.org/0000-0002-4962-2711)
- Robert C. Kurtz (ORCID: https://orcid.org/0009-0002-6493-3136)
- Steven C. Moore (ORCID: https://orcid.org/0000-0002-8169-1661)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-1226-070X)
- Mengmeng Du
- Verena Katzke
- Ann Schwartz
- M I Stampfer
- Jones
- Steven Gallinger
- Charles C. Chung
- Loic LeMarchand
- Chad Huff
- WP Lee
- A Heather Eliassen
- Natalia Cabrera
- Jennifer B. Permuth
- M C Southey
- G G Giles
- Caroline Um
- Jeanine Genkinger
- Sonja I Berndt
- Laura Beane-Freeman
- Nathaniel Rothman
- Lorelei Mucci
- David McKean
- Harvey A. Risch
- Manolis Kogevinas
- Michael Goggins
- Demetrius Albanes
- Paul Brennan
- J. Michael Gaziano
- Laia Peruchet
- Kala Visvanathan
- Jun Zhong (ORCID: https://orcid.org/0000-0002-3700-9434)
- Roger Milne
- Daniele Campa
- Charles Kooperberg
- Veronica W Setiawan
- Belynda Hicks
- Fulvio Ricceri
- Alpa V Patel
- Daniel Laheru
- Francisco X Real
- Christopher A Haiman
- Ulrike Peters
- Walter C Willett
- Stephen J Chanock
- Peter Kraft
- Edward L Giovannucci
- Paige M. Bracci
- Julie E Buring
- Manal Hassan
- Nicolas Wentzensen
Institutions
- University of Pisa (IT)
- University of Southern California (US)
- University of Hawaiʻi at Mānoa (US)
- Universitat Autònoma de Barcelona (ES)
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Fox Chase Cancer Center (US)
- National Institutes of Health (US)
- Bloomberg (United States) (US)
- University of Hawaii System (US)
- Memorial Sloan Kettering Cancer Center (US)
- Texas Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- Universitat Pompeu Fabra (ES)
- German Cancer Research Center (DE)
- University of California, San Francisco (US)
- Wayne State University (US)
- Cancer Council Victoria (AU)
- Vanderbilt University (US)
- Lunenfeld-Tanenbaum Research Institute (CA)
- QIMR Berghofer Medical Research Institute (AU)
- Heidelberg University (DE)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- VA Boston Healthcare System (US)
- Moffitt Cancer Center (US)
- Yale University (US)
- Fred Hutch Cancer Center (US)
- Spanish National Cancer Research Centre (ES)
- Center for Research in Environmental Epidemiology (ES)
- Cancer Center of Hawaii (US)
- Quantitative BioSciences (US)
- NIHR Imperial Biomedical Research Centre (GB)
- Dana-Farber Cancer Institute (US)
- Monash Health (AU)
- Mayo Clinic in Arizona (US)
- Frederick National Laboratory for Cancer Research (US)
- Hospital Del Mar (ES)
- Municipal Institute for Medical Research (ES)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Barcelona Institute for Global Health (ES)
- Melbourne Clinic (AU)
- Department of Public Health (US)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Department of Health and Human Services (US)
- Centre international de recherche sur le cancer (FR)
- University of Hawaii Cancer Center
- Imperial College London (GB)
- Monash University (AU)
- New York University (US)
- University at Buffalo, State University of New York (US)
- Columbia University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.21.26351329
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute