Transcription factor collaboration enables precise T cell state engineering
T cell states, and show that tethering TFs enables the rational engineering of cell state identity for cell and gene therapies.
Authors
- Hung‐Che Kuo (ORCID: https://orcid.org/0000-0002-8577-1706)
- Rachel E. Savage (ORCID: https://orcid.org/0000-0001-6415-7881)
- Jason D. Buenrostro (ORCID: https://orcid.org/0000-0001-9958-3987)
- Max A. Horlbeck (ORCID: https://orcid.org/0000-0002-3875-871X)
- Charles A. Gersbach (ORCID: https://orcid.org/0000-0003-1478-4013)
- Ruochi Zhang
- Christian D. McRoberts Amador
- Aretha R. Gao
- Conrad T. Hock (ORCID: https://orcid.org/0009-0004-2722-2399)
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Duke University (US)
- Genetic Technologies (Australia) (AU)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.20.718569
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00