Bone‐Targeted Nanoparticles Enable Metabolic Reprogramming via cGAS Lactylation Suppression to Restore Chemosensitivity and Antitumor Immunity in Osteosarcoma
@Mi markedly sensitizes OS to cisplatin, remodels the immunosuppressive tumor microenvironment, and suppresses tumor growth. Importantly, robust therapeutic efficacy is further validated in a patient-derived xenograft model established from post-chemotherapy recurrent OS, highlighting its translational potential. Collectively, this work presents a nanomaterial-enabled strategy to overcome chemoresistance through modulation of the metabolic-immune axis.
Authors
- Yueqiang Zhang (ORCID: https://orcid.org/0000-0003-4353-593X)
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- D Wang
- Qing Deng (ORCID: https://orcid.org/0000-0001-5116-461X)
- Chuqi Cong
- J Z Zeng
- Jinglei Miao
- Jinsong Li
- Zixin Li
- Zhaochen Tong (ORCID: https://orcid.org/0009-0003-9414-9817)
- Sijie Wen
- Shijie Chen (ORCID: https://orcid.org/0000-0003-3385-9252)
- Lingpu Zhang (ORCID: https://orcid.org/0009-0005-0029-3979)
- Haihua Xiao (ORCID: https://orcid.org/0000-0001-8159-8187)
- Zheng Cao
- Weiguo Wang
- Yi Peng
Institutions
- Central South University (CN)
- Hunan University (CN)
- National University of Defense Technology (CN)
- Science Exchange (United States) (US)
- Beijing National Laboratory for Molecular Sciences (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1002/adma.73147
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China