treestructure: An R package to detect population structure in phylogenetic trees

MOTIVATION: How population structure can shape genetic diversity is a longstanding problem in population genetics. While the use of geographic locations, when available, can help answer some of these questions, it is still difficult to determine population structure when such metadata is not available or when the potential population structure is not easily observed. Here we present an updated version of treestructure, an R package that implements a statistical test based on coalescent theory to detect unobserved population structure in a time-scaled phylogenetic tree. AVAILABILITY: treestructure is available at CRAN at https://cloud.r-project.org/web/packages/treestructure/ and at https://emvolz-phylodynamics.github.io/treestructure/.

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Publication Details

Journal
Bioinformatics
Published
2026-04-20
DOI
https://doi.org/10.1093/bioinformatics/btag195
Primary Topic
Genetic diversity and population structure
Type
article
Field-Weighted Citation Impact
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article

treestructure: An R package to detect population structure in phylogenetic trees

Vinícius Bonetti Franceschi, Erik Volz, Fabrícia F Nascimento
Bioinformatics
Genetic diversity and population structure
article

treestructure: An R package to detect population structure in phylogenetic trees

Vinícius Bonetti Franceschi, Erik Volz, Fabrícia F Nascimento
article en

Abstract

MOTIVATION: How population structure can shape genetic diversity is a longstanding problem in population genetics. While the use of geographic locations, when available, can help answer some of these questions, it is still difficult to determine population structure when such metadata is not available or when the potential population structure is not easily observed. Here we present an updated version of treestructure, an R package that implements a statistical test based on coalescent theory to detect unobserved population structure in a time-scaled phylogenetic tree. AVAILABILITY: treestructure is available at CRAN at https://cloud.r-project.org/web/packages/treestructure/ and at https://emvolz-phylodynamics.github.io/treestructure/.

Bioinformatics
London Centre for Neglected Tropical Disease Research (GB)
Openalex Percentile: Top 7%
Genetic diversity and population structure
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