Mitochondrial NADP+-isocitrate dehydrogenase Idp1 involves CoQ biosynthesis in parallel with NAD kinase Pos5
Mitochondrial NADPH is synthesized by isocitrate dehydrogenase (Idp1) from NADP+ and NAD kinase (Pos5) from NADH. Coenzyme Q levels in Schizosaccharomyces pombe were decreased by deletion of idp1 and further lowered by deletion of pos5. The NADP+/NADPH ratio of the ∆idp1 strain shifted to an oxidized state. The mitochondrial NADPH pool and its redox state are critical for CoQ biosynthesis.
Authors
- Shogo Nishihara
- Yasuhiro Matsuo (ORCID: https://orcid.org/0000-0002-2858-7179)
- Makoto Kawamukai (ORCID: https://orcid.org/0000-0003-2929-8798)
Institutions
- Shimane University (JP)
- Tottori University (JP)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1093/bbb/zbag059
- Primary Topic
- Coenzyme Q10 studies and effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00