Mediator Tail Subunits Hierarchically Couple Transcriptional Condensates to Gene Activation and Genome Organization
transcription and gene coalescence. Together, our findings establish a modular and hierarchical organization of the Mediator Tail that integrates phase separation, transcriptional condensate composition, and 3D genome architecture to drive rapid stress-induced gene activation.
Authors
- David S. Gross (ORCID: https://orcid.org/0000-0002-7957-8790)
- Gurranna Male (ORCID: https://orcid.org/0000-0003-2544-6626)
- Linda S Rubio (ORCID: https://orcid.org/0000-0002-7260-6971)
- Suman Mohajan (ORCID: https://orcid.org/0000-0002-8913-9425)
Institutions
- Louisiana State University in Shreveport (US)
- Louisiana State University Health Sciences Center Shreveport (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.21.719956
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health