A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against <i>Borrelia burgdorferi</i>
transstadial transmission within tick populations. Our findings advance development of reservoir targeted solutions for Lyme disease prevention. Further evaluation of impacts on incidental hosts is needed.
Authors
- Paige Witucki
- Greg Joyner (ORCID: https://orcid.org/0000-0001-9333-6600)
- Kurayi Mahachi (ORCID: https://orcid.org/0000-0002-8642-3797)
- Tyler Baccam
- Suman Kundu (ORCID: https://orcid.org/0000-0002-8591-1166)
- Christine A. Petersen (ORCID: https://orcid.org/0000-0002-7285-4254)
- José F. Azevedo
- Eric Kontowicz (ORCID: https://orcid.org/0000-0003-1323-4925)
- Max Waugh
- Grant Brown (ORCID: https://orcid.org/0000-0002-7247-7313)
- Ferney Henao-Ceballos
- Amy Schwartz
- Kathryn Arnold
- Julia Poje
- Nisha Nair
- Felix Pabon-Rodriguez
- Maryland Field Team
- Maria Gomes-Solecki
Institutions
- University of Iowa (US)
- University of Tennessee Health Science Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.21.719976
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00