Evaluating self- and informant-reported complaints as predictors of cognitive progression in subjective cognitive decline: A clinically-based evaluation
were associated with a more pronounced decline across all cognitive composites exceeding the predictive value of the QPC-total score. Several other memory- and non-memory-related complaints showed associations in the same direction but did not consistently remain significant after correction.ConclusionsIn older adults with SCD, focusing on specific SCCs, particularly informant-reported memory complaints, rather than relying solely on global SCC score, allows more targeted identification of individuals whose complaints are most consistently associated with longitudinal cognitive decline. Structured assessments integrating informant perspective may improve early risk stratification.
Authors
- Adéla Fendrych Mazancová (ORCID: https://orcid.org/0000-0002-2132-0690)
- Tomáš Nikolai (ORCID: https://orcid.org/0000-0002-0104-7228)
- Veronika Matušková (ORCID: https://orcid.org/0000-0002-5033-1049)
- Martin Vyhnálek (ORCID: https://orcid.org/0000-0002-5976-4932)
- Kateřina Sheardová (ORCID: https://orcid.org/0000-0002-7731-1996)
- Ross Andel (ORCID: https://orcid.org/0000-0003-4083-4790)
- Jakub Hort (ORCID: https://orcid.org/0000-0002-1080-3726)
- Dylan J. Jester (ORCID: https://orcid.org/0000-0001-9878-9633)
- Jan Laczó (ORCID: https://orcid.org/0000-0003-3186-2669)
- Ondřej Lerch (ORCID: https://orcid.org/0000-0002-8030-0905)
- Terezie Vohrádková
Institutions
- VA Palo Alto Health Care System (US)
- Charles University (CZ)
- University Hospital in Motol (CZ)
- University Hospital Brno (CZ)
- St. Anne's University Hospital Brno (CZ)
- Arizona State University (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2026-04-23
- DOI
- https://doi.org/10.1177/13872877261443656
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00