Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of <i>Mycobacterium tuberculosis</i> Displaying Enhanced Metabolic Stability
coadministered with 1-aminobenzotriazole (ABT) exhibited bactericidal activity. These findings provide key strategies for improving potency and pharmacokinetic properties toward a tractable preclinical candidate.
Authors
- Nada Mosallam (ORCID: https://orcid.org/0000-0001-7028-4190)
- Neil G. Berry (ORCID: https://orcid.org/0000-0003-1928-0738)
- Daire Cantillon (ORCID: https://orcid.org/0000-0002-2180-373X)
- Paul J. Converse
- Paul M. O’Neill (ORCID: https://orcid.org/0000-0003-4338-0317)
- Giancarlo A. Biagini (ORCID: https://orcid.org/0000-0001-6356-6595)
- Gemma L. Nixon (ORCID: https://orcid.org/0000-0002-9730-0960)
- Dirk Bald (ORCID: https://orcid.org/0000-0003-3067-0024)
- Laura N. Jeffreys (ORCID: https://orcid.org/0000-0002-0607-6116)
- W. David Hong (ORCID: https://orcid.org/0000-0002-0030-3007)
- Christopher M. Woodley (ORCID: https://orcid.org/0000-0003-1311-4288)
- Alison Ardrey
- Monika Lisauskaitė (ORCID: https://orcid.org/0009-0000-1364-5439)
- Ilinca Memelis
- Jin Lee
- Deepak Almeida
- Eric L. Nuermberger
Institutions
- Johns Hopkins University (US)
- University of Liverpool (GB)
- Liverpool School of Tropical Medicine (GB)
- Johns Hopkins Medicine (US)
- Drugs & Diagnostics for Tropical Diseases (US)
- National Institute of Research in Tuberculosis (IN)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-23
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03274
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council