Stage-dependent endoplasmic reticulum homeostasis in osteogenic differentiation
homeostasis, and lipid metabolism during osteogenic differentiation from the perspective of ER structure-function coupling. We further discuss potential therapeutic strategies targeting ER stress regulation, including chemical chaperones and UPR/autophagy modulators, to provide new insights for targeted therapeutic approaches for osteoporosis.
Authors
- Shangzeng Wang
- Y Zhang
- Xiangpeng Lu
- Jili Wang (ORCID: https://orcid.org/0000-0002-8976-508X)
- Linyi Wang
- Xiaokun Dong
- Xiaoyu Li
- Xiaoge Wang
Institutions
- Second Affiliated Hospital of Zhengzhou University (CN)
- Luohe Medical College (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-04-23
- DOI
- https://doi.org/10.3389/fcell.2026.1809292
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00