Unique nasal cell states induced by common pediatric respiratory viruses
hillock-like squamous epithelial subset enriched for expression of childhood-onset asthma risk loci. Finally, we demonstrate that this resource enables high-resolution annotation of independent pediatric cohorts in Kolkata, India and rural Bangladesh. Together, this atlas establishes a comprehensive view of antiviral immunity in the pediatric nasal mucosa and defines virus-specific mucosal immune programs relevant to disease severity and asthma risk in early life.
Authors
- Senjuti Saha (ORCID: https://orcid.org/0000-0001-6087-6766)
- Lael M. Yonker (ORCID: https://orcid.org/0000-0003-1711-8227)
- Yogesh Hooda (ORCID: https://orcid.org/0000-0002-7181-9254)
- Abdul Karim Sesay (ORCID: https://orcid.org/0000-0002-4746-0974)
- Ying Tang (ORCID: https://orcid.org/0000-0003-4357-2343)
- Apurba Rajib Malaker (ORCID: https://orcid.org/0000-0003-3879-8890)
- Supratim Ghosh (ORCID: https://orcid.org/0000-0001-8538-600X)
- Wanda I. Gonzalez (ORCID: https://orcid.org/0000-0002-7049-3555)
- Corrine Sin Quee
- Jessica Edwards
- T I de Silva
- Sarah Camille Glover (ORCID: https://orcid.org/0000-0002-9899-0473)
- Faith Taliaferro
- Kyle Kimler (ORCID: https://orcid.org/0000-0003-4735-9064)
- Abigail Kane (ORCID: https://orcid.org/0000-0001-7593-6151)
- Apurba Ghosh
- Preonath Chondrow Dev (ORCID: https://orcid.org/0000-0002-6885-2379)
- Lillian J. Juttukonda (ORCID: https://orcid.org/0000-0002-4985-8505)
- Jaclyn M. Long (ORCID: https://orcid.org/0000-0001-6292-1006)
- Charles A. Coomer (ORCID: https://orcid.org/0000-0003-2523-6485)
- Surupa Basu (ORCID: https://orcid.org/0000-0002-9455-5941)
- Deb Purna Keya
- A Chatterjee (ORCID: https://orcid.org/0000-0002-0619-0728)
- Partha Majumder
- Lubana Tanvia (ORCID: https://orcid.org/0009-0002-5919-7162)
- Amanda Frischmann
- Bruce H. Horwitz
- Jose Ordovas-Montanes
- Arif Mohammad Tanmoy (ORCID: https://orcid.org/0000-0002-7769-8035)
- Alex K. Shalek
- Erica Langan
- Hannah R. Matthews
- Chris M. Lent
- Marc Elosua-Bayes
- Arindam Maitra
Institutions
- Broad Institute (US)
- Boston University (US)
- Tulane University (US)
- Boston Medical Center (US)
- Boston Children's Hospital (US)
- Massachusetts Department of Public Health (US)
- Harvard University (US)
- Child In Need Institute (IN)
- Ragon Institute of MGH, MIT and Harvard (US)
- Massachusetts General Hospital (US)
- Harvard Affiliated Emergency Medicine Residency (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- University of the West Indies (BS)
- IIT@MIT (US)
- MRC Unit the Gambia (GM)
- Princess Margaret Hospital (NZ)
- Institute of Child Health (IN)
- Child Health Research Foundation (BD)
- Usha Martin (India) (IN)
- Boston Children's Museum (US)
- Harvard Stem Cell Institute (US)
- National Institute of Biomedical Genomics (IN)
- Massachusetts Institute of Technology (US)
- Indian Statistical Institute (IN)
- University of Sheffield (GB)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.20.719671
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00