From <i>Drosophila</i> to mammals: The evolutionarily conserved homeodomain protein Engrailed affects the antitumor innate immune response
genes in mammals and flies, which is further illustrated by the phenotypes induced in fly wings and tumor load after ectopic expression of mammalian genes in flies.
Authors
- Jieqing Huang (ORCID: https://orcid.org/0000-0002-4138-5109)
- DJ Chen
- Zihao Deng (ORCID: https://orcid.org/0000-0001-5702-6648)
- Zhenming Cao (ORCID: https://orcid.org/0000-0002-7905-8146)
- J S Chen
- Xiaoming Huang (ORCID: https://orcid.org/0000-0001-5602-9150)
- Yuqiang Chen (ORCID: https://orcid.org/0000-0002-0646-7571)
- Ziming Wei
- Xiaojing Zhou (ORCID: https://orcid.org/0000-0003-2150-3400)
- Yuntong Yuan
- Mo Liu
- Mengyu Jiu
- Renjie Jiao (ORCID: https://orcid.org/0000-0002-3918-7656)
- Hua Cai
- Zhenhui Ye
- Jiyong Liu
- Yanzhen He
- Jules A. Hoffmann
- Yuhong Zhang
Institutions
- Institut de Biologie Moléculaire et Cellulaire (FR)
- Université de Strasbourg (FR)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-23
- DOI
- https://doi.org/10.1073/pnas.2603878123
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangzhou Municipal Science and Technology Bureau
- National Key Research and Development Program of China
- International Science and Technology Cooperation Programme