Topical Glucocorticosteroids for Proactive Therapy of Acute Radiation-Induced Skin Injury in Head and Neck Cancer: A Systematic Review and Meta-Analysis with Trial Sequential Analysis
Proactive topical GCS do not significantly reduce the overall incidence of aRISI in pooled analysis. Individual studies showed trend towards delayed onset, slower progression, and reduced severe aRISI without compromising safety. These findings support the judicious use of topical GCS as part of proactive supportive care in HNC RT, while highlighting the need for larger, standardized trials to define optimal regimens and patient selection.
Authors
- Joanna Kaźmierska (ORCID: https://orcid.org/0000-0001-7160-8150)
- Aleksandra Dańczak‐Pazdrowska (ORCID: https://orcid.org/0000-0002-8192-7013)
- Paweł Głuszak (ORCID: https://orcid.org/0000-0002-5877-491X)
- Jakub Pazdrowski (ORCID: https://orcid.org/0000-0002-6065-6402)
- Andrzej Bałoniak (ORCID: https://orcid.org/0009-0007-5517-5587)
- Julia Woźna (ORCID: https://orcid.org/0009-0006-3659-2580)
- Jan Stępka
Institutions
- Poznan University of Medical Sciences (PL)
- Greater Poland Cancer Center (PL)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-21
- DOI
- https://doi.org/10.3390/biomedicines14040942
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00