Disrupting SRSF10-dependent BCAT2 exon skipping reprograms tumor-associated macrophages and enhances anti-PD-1 efficacy in gastric cancer
orthotopic GC models. Collectively, our findings revealed that SRSF10 orchestrates mTOR-CCL2 signaling by alternative RNA splicing of BCAT2 to reprogram TAMs, proposing SRSF10 as a tempting therapeutic target for GC immunotherapy.
Authors
- You-Xin Gao
- Qi‐Yue Chen (ORCID: https://orcid.org/0000-0001-6391-4043)
- Ling-Qian Wang
- Chang‐Ming Huang (ORCID: https://orcid.org/0000-0002-0019-885X)
- Chenyang Jiang (ORCID: https://orcid.org/0000-0002-0199-3353)
- Xiao-Qian Ye
- Xiao-Jing Guo (ORCID: https://orcid.org/0000-0001-6489-0717)
- Yifan Li (ORCID: https://orcid.org/0000-0003-3217-8893)
- Ping Li (ORCID: https://orcid.org/0000-0003-0332-867X)
- Jian‐Wei Xie (ORCID: https://orcid.org/0000-0003-4971-2896)
- Xin-Peng Yang
- Jia-Bin Wang
- Jian-Xian Lin
- Hua-Long Zheng
- Bin Lin
- Xiao-Bo Huang
- Yun-Lin Chen
- Chao-Hui Zheng
- Qiang Huang
- Yi Li (ORCID: https://orcid.org/0000-0002-7652-2265)
Institutions
- Fujian Medical University (CN)
- Union Hospital (US)
- Union Hospital (CN)
Publication Details
- Journal
- Cell Death and Disease
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41419-026-08622-3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00