Therapeutic intervention strategies for Nipah virus infection: a scoping review

INTRODUCTION: Nipah virus (NiV) infection, a zoonotic disease, has caused recurrent outbreaks in South and Southeast Asia, with case fatality rates ranging from 38% to 75%. The clinical management of NiV disease (NiVD) relies on supportive care, with unapproved antiviral therapies and no licensed vaccines currently available. OBJECTIVES: This scoping review aims to synthesise and map the available evidence on therapeutic strategies for NiV infection. METHODS: analyses evaluating NiV therapies. Eligible studies were selected based on their population or experimental model, therapeutic intervention, evaluation methods, efficacy outcomes, safety findings and proposed molecular mechanisms. RESULTS: gap exists between the urgent clinical need for effective treatments and the limited availability of clinically validated therapies. CONCLUSION: Effective, clinically validated therapies for NiV infection are still lacking. Translational research, outbreak-ready clinical trial frameworks and prioritisation of promising therapeutic candidates are crucial for improving preparedness and clinical outcomes in future NiV outbreaks.