Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems
). This variant was identified near the PLXNC1 gene. The eQTL analysis identified the role of the SOCS2 gene. Our study demonstrated the role of genes, PLXCN1 and SOCS2, that contribute to frailty through neurological and immunological pathways.
Authors
- Marie Pigeyre (ORCID: https://orcid.org/0000-0003-2984-8366)
- Lauren E. Griffith (ORCID: https://orcid.org/0000-0002-2794-9692)
- Sayem Borhan (ORCID: https://orcid.org/0000-0002-2821-0849)
- G P Pare
- Le Minh An Nguyen
- Jonathan Adachi
- Alexandra Papaioannou
- Lehana Thabane
- Parminder Raina
Institutions
- Impact (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
Publication Details
- Journal
- npj Aging
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41514-026-00363-z
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Canada
- Canadian Institutes of Health Research