Reprogramming Disulfide Reduction in Endoplasmic Reticulum Uncouples Immune Evasion of Pancreatic Cancer
I mediate continuous disulfide bond reduction, blocking CD47 folding and surface translocation, resulting in a 93.6% reduction in CD47 expression. Together with the remarkable increase of tumor antigen presentation induced by ER reductive stress in pancreatic tumor-bearing mice, we realize a 93% tumor inhibition and a 3-fold prolongation of survival. This work underscores the role of organellar biochemistry in reshaping immunosuppression for tumor immunotherapy.
Authors
- T Wang
- Peiran Zhao (ORCID: https://orcid.org/0000-0002-7643-8215)
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Li Zhang (ORCID: https://orcid.org/0000-0001-8142-403X)
- Zhongqiu Guo
- Yuting Lu (ORCID: https://orcid.org/0009-0003-8296-8727)
- Changjing Zuo (ORCID: https://orcid.org/0000-0002-4179-2302)
- Yelin WU
- Wenbo Bu (ORCID: https://orcid.org/0000-0001-6664-3453)
- Yang Chen
- Fan Wu
- Wenjun Gu
Institutions
- Fudan University (CN)
- Shanghai East Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1002/adma.202517261
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China