Novel Pyrido[4,3- <i>d</i> ]pyrimidine Derivatives as Kirsten Rat Sarcoma (KRAS) G12C Potential Inhibitors
This highlight describes novel substituted 2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidine derivatives as potential inhibitors for Kirsten Rat Sarcoma (KRAS) G12C, which is extensively expressed across a variety of cancers. The patent provides detailed description of the preparation routes, methods of use, biological activity evaluations, and pharmaceutical compositions.
Authors
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
- Ruihu Song
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00190
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00