Temperature-Dependent Bioaccumulation of Metals in Marine Mollusks: Integrating Thermal Performance Curves, Machine Learning, and Toxicokinetic Modeling

≈ 0.73). Across the compiled evidence, filtration and growth showed strong species-specific thermal sensitivity, while metal chemistry primarily structured uptake. In the limited multitemperature TK calibration data set, a positive association between temperature and elimination was observed, but this relationship should be regarded as provisional pending additional multitemperature uptake-depuration data sets. By explicitly representing temperature-sensitive filtration and turnover pathways, the approach enables scenario testing for warming and heat extremes and provides a practical basis for improving the interpretation of bioaccumulation factors, seasonal biomonitoring, and temperature-aware risk assessment under climate change.