Unlocking Spatiotemporal Dynamics: Precise Dual-Modal Bioimaging of Endogenous c-MYC mRNA in Tumors via a CHA-Activated Ratiometric Nanoplatform
, and the afterglow signal of ZGMD was observed within 6 min in mice after preirradiation, which unlocked spatiotemporal dynamics of dual-modal bioimaging. Importantly, the ZGMD nanoplatform could visualize the dynamic fluctuations of endogenous c-MYC within tumors by dual-modal spatiotemporal bioimaging, providing a noninvasive tool for real-time assessment in disease diagnosis and cancer therapy.
Authors
- Keqi Tang (ORCID: https://orcid.org/0000-0003-0316-6850)
- Xiangwu Wu
- Shengrong Yu (ORCID: https://orcid.org/0000-0003-1398-2253)
- Yong‐Xiang Wu (ORCID: https://orcid.org/0000-0003-1054-2105)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Tingfeng Ma
- Tao Zhang
- Zhirong Liu
- Rong Feng
- Yuhang Zhang
Institutions
- Ningbo University (CN)
- Smart Material (Germany) (DE)
- IONICS Mass Spectrometry (Canada) (CA)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acs.analchem.6c01305
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Ningbo Municipal Bureau of Science and Technology
- State Key Laboratory of Chemo/Biosensing and Chemometrics
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province
- Key Research and Development Program of Zhejiang Province