Design, synthesis and biological evaluation of a 4,6-di(aziridin-1-yl)-1,3,5-triazine–benzimidazole hybrid as a potential dual-targeting anticancer agent
AIMS: This study aimed to develop a novel aziridine-1,3,5-triazine derivative combining DNA-alkylating aziridine rings with a benzimidazole-containing fragment associated with PARP-related chemotypes. MATERIALS AND METHODS: in A549 and HCT-116 xenografts in immunodeficient BALB/c Nude mice. RESULTS: < 0.05) and demonstrated dose-dependent activity in HCT-116 xenografts (up to 82.9% TGI at 6 mg/kg, i.v.).
Authors
- Ilya V. Kornyakov (ORCID: https://orcid.org/0000-0002-8904-6149)
- Ivan S. Chernov
- Olga V. Mikolaichuk (ORCID: https://orcid.org/0000-0002-0463-7725)
- Natalia V. Petukhova (ORCID: https://orcid.org/0000-0001-6397-824X)
- Vadim S. Pokrovsky (ORCID: https://orcid.org/0000-0003-4006-9320)
- Vladimir V. Sharoyko (ORCID: https://orcid.org/0000-0002-3717-0471)
- Olga S. Shemchuk (ORCID: https://orcid.org/0000-0003-3060-2232)
- A. V. Protas (ORCID: https://orcid.org/0000-0002-1920-9360)
- Gulalek Babayeva (ORCID: https://orcid.org/0000-0001-5781-7925)
- Vyacheslav E. Bulakov
- Pavel K Kozhukhov
- Konstantin N. Semenov
- Valeria M. Tretiakova (ORCID: https://orcid.org/0009-0008-3562-2535)
Institutions
- Peoples' Friendship University of Russia (RU)
- Russian Academy of Sciences (RU)
- St Petersburg University (RU)
- First Pavlov State Medical University of St. Petersburg (RU)
- Togliatti State University (RU)
- Russian Cancer Research Center NN Blokhin (RU)
- Russian Scientific Center of Radiology and Surgical Technologies (RU)
- Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1080/17568919.2026.2658014
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00