Metal‐Free Synthesis of Indolo[3,2‐ <i>c</i> ]quinolines via S <sub>8</sub> ‐Mediated Hydrogen‐Borrowing Reduction/Cyclization/Aromatization Sequence
A S 8 ‐mediated hydrogen‐borrowing reduction/cyclization/aromatization strategy for the preparation of indolo[3,2‐ c ]quinolines has been described. The present procedure starts from 2‐(2‐nitrophenyl)indoles and amines, providing a wide range of indolo[3,2‐c]quinolines in 39%–75% yields under metal‐free conditions. In this work, nitro‐group reduction, CN bond cleavage, CN bond formation, and cyclization are achieved in one pot.
Authors
- Bin Tan (ORCID: https://orcid.org/0000-0001-8219-9970)
- Shanping Chen
- Guo‐Jun Deng (ORCID: https://orcid.org/0000-0003-2759-0314)
- Jiao Liu (ORCID: https://orcid.org/0009-0009-2878-5261)
- Yang Li
- Zeng Cheng
- Yuxia Li (ORCID: https://orcid.org/0009-0009-2227-9501)
Institutions
- Xiangtan University (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1002/adsc.70444
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China