Multiple clades of regulators contribute to bacterial phosphate homeostasis and <i>Staphylococcus aureus</i> pathogenesis
, this work demonstrates that these regulatory proteins function in an environment-dependent hierarchy to control phosphate balance. During host infection, multiple accessory regulators are independently necessary. This regulatory expansion represents a fundamental strategy by which bacteria adapt phosphate acquisition to their surroundings, particularly within a dynamic host environment.
Authors
- Bin He (ORCID: https://orcid.org/0000-0002-3072-6238)
- Thomas E. Kehl‐Fie (ORCID: https://orcid.org/0000-0001-8234-1113)
- Jana N. Radin (ORCID: https://orcid.org/0000-0003-1783-7336)
- Gary J. Olsen
- Caroline Vermilya
- Eliot S. Joya Sandoval
Institutions
- University of Iowa (US)
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- mBio
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1128/mbio.00203-26
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Iowa
- National Institutes of Health
- University of Illinois at Urbana-Champaign