Real-World Outcomes of Chemiluminescence Immunoassay Implementation for <i>Mycobacterium tuberculosis</i> Infection Screening
Unstructured Abstract Fully automated CLIA-based interferon gamma release assays (IGRA) promise more efficient testing for tuberculosis infection but increase positive test rates compared to semi-automated assays. We report an increase in borderline-positive IGRA results (87.8% relative increase, 95% CI: 31.1–170.0%) which led to modifications in clinical care following CLIA assay implementation.
Authors
- Yun F. Wang (ORCID: https://orcid.org/0000-0002-7286-4866)
- Bruce Aldred (ORCID: https://orcid.org/0009-0008-3034-9947)
- Paulina A. Rebolledo
- Eli Wilber (ORCID: https://orcid.org/0000-0001-8413-2681)
- Sheetal Kandiah
- Susan M Ray
- Marcos C Schechter
Institutions
- Emory University (US)
- Grady Health System (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-04-21
- DOI
- https://doi.org/10.1093/ofid/ofag234
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00