Activation of nociceptin receptor attenuates methamphetamine motivation and relapse in rats: Involvement of phosphorylated CREB and Akt in the nucleus accumbens.

< 0.05). These behavioral effects were related to the upregulated phosphorylation of CREB and Akt in the NAc. Our results provide preclinical evidence that NOP activation disrupts multiple addiction-relevant behaviors, positioning Ro 64-6198 as a potential therapeutic candidate for treating MAP use disorders.

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Publication Details

Journal
PubMed
Published
2026-04-25
DOI
https://doi.org/10.13294/j.aps.2026.0027
Primary Topic
Neuropeptides and Animal Physiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Activation of nociceptin receptor attenuates methamphetamine motivation and relapse in rats: Involvement of phosphorylated CREB and Akt in the nucleus accumbens.

Fang-Min Wang, Zhou Yi-ying, Ding-ding Zhuang, Man-Qing Wu et al.
PubMed
Neuropeptides and Animal Physiology
article

Activation of nociceptin receptor attenuates methamphetamine motivation and relapse in rats: Involvement of phosphorylated CREB and Akt in the nucleus accumbens.

Fang-Min Wang, Zhou Yi-ying, Ding-ding Zhuang, Man-Qing Wu, Hui-Zhen Liu, Wen-Wen Shen, Miao-Jun Lai, Wen-Hua Zhou, Yu-Jia Cai
article en

Abstract

< 0.05). These behavioral effects were related to the upregulated phosphorylation of CREB and Akt in the NAc. Our results provide preclinical evidence that NOP activation disrupts multiple addiction-relevant behaviors, positioning Ro 64-6198 as a potential therapeutic candidate for treating MAP use disorders.

PubMedVol. 78(2)
Mianyang Third People's Hospital (CN), Ningbo Kangning Hospital (CN), Ningbo University Affiliated Hospital (CN)
Good health and well-being
Openalex Percentile: Top 11%
Neuropeptides and Animal Physiology
DOISourceOpenAlex
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