Mechanochemical Rh(I)-Catalyzed C–N/C–C/C–H Triple Bond Activation of Amides
Direct decarbonylative triple C-N, C-C, and C-H functionalization of amides with hydrocarbons has been accomplished under mechanochemical conditions via Rh(I) catalysis. This method exhibits excellent substrate versatility in high-yielding couplings with diverse aromatic compounds, and its utility is highlighted by late-stage pharmaceutical derivatization and orthogonal C-X and C-N sequential cross-couplings. This solvent-free mechanochemical approach drastically lowers the temperature required for triple amide activation, overcoming kinetic barriers through a sustainable pathway.
Authors
- Linqin Shang
- Jin Zhang (ORCID: https://orcid.org/0000-0002-6616-7087)
- Michal Szostak (ORCID: https://orcid.org/0000-0002-9650-9690)
- Jianbo Tong
- Renjie Li (ORCID: https://orcid.org/0000-0001-5780-7022)
- Yawei Zhu
- Siqi Jiang (ORCID: https://orcid.org/0000-0002-2435-9005)
- Nana Chen
Institutions
- Rutgers, The State University of New Jersey (US)
- New Jersey Institute of Technology (US)
- Shaanxi University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acs.orglett.6c01505
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Education Department of Shaanxi Province
- National Institute of General Medical Sciences