Nano-Power OTA-Based Low-Pass Filter for Ultra-Low-Energy Biomedical Signal Processing

This paper presents a nanowatt-scale operational transconductance amplifier (OTA) and an electronically tunable third-order low-pass filter (LPF) designed for energy-constrained biomedical signal conditioning. The circuits are implemented in a 65 nm CMOS process and verified through comprehensive schematic-level simulations. Biased in the deep subthreshold region at 1 nA, the OTA achieves a 50 dB low-frequency gain, a 225 Hz unity-gain bandwidth at 10 pF load capacitance and an input-referred noise floor of 1.55 μV/√Hz, with a total power consumption of only 1.75 nW. The integrated third-order LPF provides a wide tuning range (37–668 Hz) via bias current modulation, exhibiting excellent linearity with a THD of 0.059% and a 65.3 dB dynamic range. Monte Carlo and PVT corner analyses demonstrate the design’s theoretical robustness against process variations and environmental fluctuations. ECG signal simulations validate the circuit’s effectiveness in suppressing high-frequency artifacts while preserving morphological integrity, providing a proof-of-concept for ultra-low-power wearable healthcare architectures.