Nanoparticles that modulate immune cells - an important strategy for the future treatment of tumors

T cells proliferation or activity and reducing the number of Tregs (including nanoparticles composed of liposomes, gels, cerium, and selenium, hyaluronic acid-modified nanoparticles, nanocapsules, nanovesicles, other material nanoparticles, and nanoparticles combined with other treatment modalities), besides, some nanoparticles can exert anti-tumor activity by regulating two or more types of immune cells in the TME. In short, nanoparticles targeting immune cells will become an important strategy in tumor treatment based on the advantages of nanoparticles in enhancing efficacy and reducing toxicity in tumor therapy, as well as the important role of immune cells in tumor occurrence and development. In this article, we will provide a detailed introduction to nanoparticles that exert anti-tumor activity by regulating immune cells in the TME and briefly introduce the mechanisms by which nanoparticles regulate immune cells.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-04-22
DOI
https://doi.org/10.3389/fimmu.2026.1803646
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Nanoparticles that modulate immune cells - an important strategy for the future treatment of tumors

Xin Nie, Guoxing Zhang, Dequan Xu, Jingyuan Ren et al.
Frontiers in Immunology
Immune cells in cancer
article

Nanoparticles that modulate immune cells - an important strategy for the future treatment of tumors

Xin Nie, Guoxing Zhang, Dequan Xu, Jingyuan Ren, Lei Zhao, Haifeng Liu, Jianxin Zhao, Laga Tong, Hongbo Yan, Yan Zhao
article en

Abstract

T cells proliferation or activity and reducing the number of Tregs (including nanoparticles composed of liposomes, gels, cerium, and selenium, hyaluronic acid-modified nanoparticles, nanocapsules, nanovesicles, other material nanoparticles, and nanoparticles combined with other treatment modalities), besides, some nanoparticles can exert anti-tumor activity by regulating two or more types of immune cells in the TME. In short, nanoparticles targeting immune cells will become an important strategy in tumor treatment based on the advantages of nanoparticles in enhancing efficacy and reducing toxicity in tumor therapy, as well as the important role of immune cells in tumor occurrence and development. In this article, we will provide a detailed introduction to nanoparticles that exert anti-tumor activity by regulating immune cells in the TME and briefly introduce the mechanisms by which nanoparticles regulate immune cells.

Frontiers in ImmunologyVol. 17
Jilin Province Tumor Hospital (CN), Jilin Electric Power Research Institute (China) (CN), Taiwan Centers for Disease Control (TW), The Eighth Hospital of Xi'an (CN), Crest Middle School (US)
Good health and well-being
Openalex Percentile: Top 22%
Immune cells in cancer
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