Stereotactic arrhythmia radioablation for refractory ventricular tachycardia: the STOPSTORM.eu study.

Background And Aims Stereotactic arrhythmia radioablation (STAR) is increasingly used for refractory ventricular tachycardia (VT), yet prospective multicentre outcome data remain limited. Here, the planned interim analysis of the prospective Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) registry is reported.Methods STOPSTORM is a European prospective, international, multicentre registry of patients treated with STAR. The primary efficacy endpoint was the change in sustained VT episode burden comparing the 6 months before versus the 6 months after STAR. The primary safety endpoint was the occurrence of serious adverse events (SAEs) adjudicated as possibly or probably treatment-related. Overall survival was assessed using time-to-event methods.Results Across 28 centres, 193 patients were included (mean age 68±9 years; 88% male; 53% non-ischaemic cardiomyopathy). Median follow-up was 19 months. Among 107 evaluable patients with ≥6-month follow-up, the median VT episode burden was reduced by 80% after STAR. Among patients surviving ≥6 months, 72% were free from implantable cardioverter-defibrillator (ICD) shock. In the full cohort, 12 SAEs were adjudicated as possibly or probably treatment-related, including pericardial effusion, coronary events, and early post-treatment ventricular arrhythmia. Overall survival probability was 77% at 12 months.Conclusions In the largest prospective multicentre cohort reported to date, STAR was associated with a substantial reduction in VT burden and ICD shocks, with a low frequency of possibly or probably treatment-related SAEs.

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Publication Details

Journal
Open Access CRIS of the University of Bern
Published
2026-04-20
DOI
https://doi.org/10.48620/97177
Primary Topic
Cardiac Arrhythmias and Treatments
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article
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article

Stereotactic arrhythmia radioablation for refractory ventricular tachycardia: the STOPSTORM.eu study.

Marzia Cerrato, Wiert F. Hoeksema, Étienne Pruvot, Sławomir Blamek et al.
Open Access CRIS of the University of Bern
Cardiac Arrhythmias and Treatments
article

Stereotactic arrhythmia radioablation for refractory ventricular tachycardia: the STOPSTORM.eu study.

Marzia Cerrato, Wiert F. Hoeksema, Étienne Pruvot, Sławomir Blamek, Roland Merten, Bartłomiej Tomasik, Annika Lattermann, Mateusz Sajdok, Günther Klautke, Boldizsar Kovacs, Corrado Carbucicchio, Adrian Zaman, Stefan Jaschik, Moritz F. Sinner, Stefano Mandija, Mathieu Kruska, Jakub Cvek, Veronica Dusi, Felix B. Mehrhof, Javier Quesada-Ocete, Ajra Šečerov Ermenc, Michele Magnocavallo, Judit Boda‐Heggemann, M. Algara, Tomasz Jadczyk, Melanie Grehn, David A. Krug, Tomasz Latusek, Giulio Molon, Dirk Rades, Felix Hohendanner, Luis Schiappacasse, Mauro Iori, Olgun Eliçin, Maiwand Ahmadsei, Jiří Plášek, Jasna But Hadžić, Matteo Anselmino, Jacek Bednarek, Jingyang Xie, Colien Hazelaar, Mario Levis, Micaela Ebert, Francesco Cellini, David Duncker, Lukas Seiß, Thomas Brunner, Brian V. Balgobind, Marian Christoph, Chiara Crico, Robert Rademaker, Lukáš Knybel, Marc D. Lemoine, Ardan Saguner, Franziska Hausmann, Rachel M A Ter Bekke, Coen R N Rasch, Joost J C Verhoeff, Niccolò Giaj-Levra, Katja Zeppenfeld, Claudia Herrera Siklody, Lukasz Dolla, Daniel Scherr, Joanna Kaminska, L H G van der Pol, Barbara A Jereczek-Fossa, Roland Tilz, Maria Del Pino Alcantara, Gustavo Pozo Rodigriuez, Marcin Miszczyk, David Calvo, Christian Veltmann, Gaetano Maria De Ferrari, Nicolaus Andratschke, Piedad Almendros Blanco, Oliver Blanck, Bor Antolic, Otakar Jiravsky, Gerhard Hindricks, Jorge Solana Munoz, M F Fast, Stefanie Corradini, Evgeny Lian, Pieter P G Postema
article en

Abstract

Background And Aims Stereotactic arrhythmia radioablation (STAR) is increasingly used for refractory ventricular tachycardia (VT), yet prospective multicentre outcome data remain limited. Here, the planned interim analysis of the prospective Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) registry is reported.Methods STOPSTORM is a European prospective, international, multicentre registry of patients treated with STAR. The primary efficacy endpoint was the change in sustained VT episode burden comparing the 6 months before versus the 6 months after STAR. The primary safety endpoint was the occurrence of serious adverse events (SAEs) adjudicated as possibly or probably treatment-related. Overall survival was assessed using time-to-event methods.Results Across 28 centres, 193 patients were included (mean age 68±9 years; 88% male; 53% non-ischaemic cardiomyopathy). Median follow-up was 19 months. Among 107 evaluable patients with ≥6-month follow-up, the median VT episode burden was reduced by 80% after STAR. Among patients surviving ≥6 months, 72% were free from implantable cardioverter-defibrillator (ICD) shock. In the full cohort, 12 SAEs were adjudicated as possibly or probably treatment-related, including pericardial effusion, coronary events, and early post-treatment ventricular arrhythmia. Overall survival probability was 77% at 12 months.Conclusions In the largest prospective multicentre cohort reported to date, STAR was associated with a substantial reduction in VT burden and ICD shocks, with a low frequency of possibly or probably treatment-related SAEs.

Open Access CRIS of the University of Bern
Good health and well-being
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Cardiac Arrhythmias and Treatments
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