N-Aryl Tetrahydroisoquinolines as Both Reagents and Substrates for Coupling with Alkyl Halides
-aryl tetrahydroisoquinoline molecule is converted into an iminium intermediate after the XAT event, which functions as an endogenous coupling partner to capture the alkyl radicals, ultimately forming C-C bonds. This transformation proceeds under redox-neutral conditions without external XAT reagents or stoichiometric reductants.
Authors
- Si-Yu You
- Zhi Guan (ORCID: https://orcid.org/0000-0002-0369-6141)
- Jie Huang
- Yan-Hong He (ORCID: https://orcid.org/0000-0002-6405-285X)
Institutions
- Southwest University (CN)
- Chongqing Municipal Government (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acs.joc.5c02930
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southwest University