Bacillus licheniformis Alleviates DSS-Induced Ulcerative Colitis in Mice by Repairing the Intestinal Barrier and Regulating Gut Microbiota and Its Metabolism

BACKGROUND: Inflammatory bowel disease (IBD) is a gut-based idiopathic disease characterized by chronic and relapsing inflammatory progression and intricate pathophysiology. It is now known that the key etiologies of IBD include immune dysregulation, imbalances in the gut microbiota, and metabolic disruptions. Probiotics are now the potential treatment for IBD, due to their ability to regulate the host immune system and microbiota of the gut. METHODS: BL-01 on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and also expounded on its molecular pathogenesis. RESULTS: BL-01 mitigates oxidative stress, reverses gut dysbiosis and metabolic disorders, and has a protective effect on UC. CONCLUSIONS: The findings give new information on the development of probiotic-based therapeutics in the prevention and treatment of IBD.