Simultaneous Inhibition of ACLY and OGDH Has a Synergistic Effect on Hepatocellular Carcinoma Cell Lines
as a synthetic lethal pair and the therapeutic potential of the VPA-BA combination treatment in HCC.
Authors
- Nagesh Kishan Panchal (ORCID: https://orcid.org/0000-0002-5504-6378)
- Mehdi Dehghan Manshadi
- Habil Zare (ORCID: https://orcid.org/0000-0001-5902-6238)
- Lu Sun
- Payam Setoodeh
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- Shiraz University (IR)
- Karolinska Institutet (SE)
- Mays Cancer Center at UT Health San Antonio (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-22
- DOI
- https://doi.org/10.64898/2026.04.19.716936
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke