Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis
. Furthermore, CASP5C is selectively induced upon intestinal epithelial injury, and its expression is increased in inflammatory bowel disease. Thus, CASP5C is an enzymatic amplifier of Wnt signalling that cleaves APC to sustain proliferation of transit-amplifying cells amid a declining Wnt gradient, safeguarding epithelial renewal. These findings broaden the roles of inflammatory caspases beyond innate immunity, uncovering their contribution to tissue homeostasis.
Authors
- Chongbo Yang
- Michael Mintz (ORCID: https://orcid.org/0000-0002-7933-3267)
- Baosen Jia
- Melissa Rose (ORCID: https://orcid.org/0009-0000-8768-4844)
- JRI Live cell bank
- Mavee Witherspoon
- J. Magarian Blander (ORCID: https://orcid.org/0000-0001-9207-1700)
- Sabine Tejpar (ORCID: https://orcid.org/0000-0003-3281-8643)
- A. Bergman (ORCID: https://orcid.org/0009-0004-3420-7699)
- Sushmita Mukherjee (ORCID: https://orcid.org/0000-0002-7645-4725)
- Alex Grier (ORCID: https://orcid.org/0000-0003-0581-9851)
- Laura Sahyoun (ORCID: https://orcid.org/0000-0002-4094-3682)
- Yourae Hong (ORCID: https://orcid.org/0000-0001-6683-433X)
- Steven M. Lipkin (ORCID: https://orcid.org/0000-0002-0603-9139)
- Vinita Jacob
- Fabrizio Michelassi
- Lauretta A. Lacko (ORCID: https://orcid.org/0000-0003-1648-2772)
- Aliza Solomon
- Jennifer Claytor (ORCID: https://orcid.org/0000-0002-4701-427X)
- Dylan Roycroft
- Kenny Joselin Castro Ochoa
- Adriana Brcic-Susak
- Dario Garone
- Maneeza Bilal
- Elliott Gordon
- Yuhua Shi (ORCID: https://orcid.org/0000-0003-4875-0719)
- Victoria Ribeiro de Godoy
- Lexi Tempera
- R Longman
- D Lukin
- Ellen Scherl
- Chloe Scott
- LCB processors
- Robbyn Sockolow
- Kelly Garrett
- LCB coordinator
- Beatrix Ueberheide
- Surgical GI
- Gregory Sonnenberg
- Jeffrey Milsom
- Bing He
- Caitlin Mason
- Lily Barash
- David Artis
- Shahida Kamal
- Kimberley Chien
- Thomas Ciecierega
Institutions
- Cornell University (US)
- Universitair Ziekenhuis Leuven (BE)
- Cancer Research UK (GB)
- New York University (US)
- KU Leuven (BE)
Publication Details
- Journal
- Nature
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41586-026-10343-8
- Citations
- 1
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 11.46