Paeoniflorin Ameliorates Liver Fibrosis by Inhibiting <scp>HIF</scp> ‐1α‐Mediated Mitophagy in Hepatic Stellate Cells
-induced liver fibrosis, effectively reducing hepatic inflammation and oxidative damage. PF also inhibited mitophagy by suppressing the HIF-1α pathway, thereby attenuating HSCs' activation. This study uncovers a novel mechanism involving HIF-1α-mediated mitophagy in HSCs and provides evidence that PF alleviates hepatic fibrosis by inhibiting this process, leading to reduced inflammation and oxidative damage. These findings suggest that PF could be a natural and vital medicine to treat liver fibrosis.
Authors
- Wenyan Jia (ORCID: https://orcid.org/0009-0009-2260-0975)
- Bin Wen (ORCID: https://orcid.org/0000-0002-3066-7717)
- Songqi He (ORCID: https://orcid.org/0000-0001-9565-4557)
- Mengchen Qin
- Ying Liu (ORCID: https://orcid.org/0000-0002-1312-0146)
- Weiguang Chen (ORCID: https://orcid.org/0000-0003-0027-7918)
- Yaou Zhou
- Binglian Zhong
- X H Yang
- Huishan Lin
- Weicong Chen
- Chunyu He
- Haitao Sun
Institutions
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Chinese People's Liberation Army (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Phytotherapy Research
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1002/ptr.70226
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province