A case report exploring the use of subcutaneous Botox for the treatment of neuropathic pain in active head and neck cancer

Patients with head and neck cancer commonly experience severe neuropathic pain. This pain is often challenging to treat and may be refractory to standard analgesic approaches. We describe the use of subcutaneous Botox injections to manage pain in such a patient. A patient with poorly differentiated carcinoma of the right base of skull with perineural invasion presented to the pain clinic with intractable facial pain. Subcutaneous Botox injections were performed. The patient experienced a significant reduction in the intensity of her pain following subcutaneous Botox injections. Subcutaneous Botox injections represent a safe and effective option for patients with head and neck cancer experiencing neuropathic pain refectory to standard analgesic medications.

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Publication Details

Journal
Pain Management
Published
2026-04-22
DOI
https://doi.org/10.1080/17581869.2026.2660148
Primary Topic
Pain Management and Opioid Use
Type
article
Field-Weighted Citation Impact
0.00
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article

A case report exploring the use of subcutaneous Botox for the treatment of neuropathic pain in active head and neck cancer

Matthew Brown, Kee H. Wong, Ellie I. Davidson, Smita L. A. Almeida
Pain Management
Pain Management and Opioid Use
article

A case report exploring the use of subcutaneous Botox for the treatment of neuropathic pain in active head and neck cancer

Matthew Brown, Kee H. Wong, Ellie I. Davidson, Smita L. A. Almeida
article en

Abstract

Patients with head and neck cancer commonly experience severe neuropathic pain. This pain is often challenging to treat and may be refractory to standard analgesic approaches. We describe the use of subcutaneous Botox injections to manage pain in such a patient. A patient with poorly differentiated carcinoma of the right base of skull with perineural invasion presented to the pain clinic with intractable facial pain. Subcutaneous Botox injections were performed. The patient experienced a significant reduction in the intensity of her pain following subcutaneous Botox injections. Subcutaneous Botox injections represent a safe and effective option for patients with head and neck cancer experiencing neuropathic pain refectory to standard analgesic medications.

Pain Management
University College of the Cayman Islands (KY), Royal Ottawa Mental Health Centre (CA), Institute of Cancer Research (CA), Royal Marsden Hospital (GB), Institute of Radiotherapy and Nuclear Medicine (PK)
Good health and well-being
Openalex Percentile: Top 6%
Pain Management and Opioid Use
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A case report exploring the use of subcutaneous Botox for the treatment of neuropathic pain in active head and neck cancer — Matthew Brown, Kee H. Wong, et al. · Pain Management (2026) | TGRS Research Map | TGRS