Transsynaptic linking of calcium channels and postsynaptic receptors at a dyadic synapse
receptors at ACh neuromuscular junctions, which elicits a retrograde increase in presynaptic strength. These results suggest that presynaptic CaV2 channels are linked to postsynaptic receptors in both targets, which allows each target to modify transmission to both targets.
Authors
- Evan L. Ardiel (ORCID: https://orcid.org/0000-0002-9366-5751)
- Joshua M. Kaplan (ORCID: https://orcid.org/0000-0001-7418-7179)
- Jian Zhao (ORCID: https://orcid.org/0000-0002-9907-0783)
- Stephen Nurrish
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Western Washington University (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1073/pnas.2603452123
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Neurological Disorders and Stroke