Imine Reductase-Catalyzed Asymmetric Synthesis of Pharmaceutically Relevant Amino-Indanes
Chiral amino-indanes are valuable pharmaceutical intermediates, yet their efficient asymmetric synthesis remains challenging. In this study, enzymatic reduction of imines using enantiocomplementary IREDs enabled the synthesis of chiral amino-indanes. Furthermore, a one-pot, two-step cascade reaction combining trimethyl borate-promoted imine formation with IRED-catalyzed imine reduction was established to produce chiral amino-indanes with 87-99% ee values via a continuous fed-batch strategy, providing environmentally friendly and economical access to these pharmaceutically relevant compounds.
Authors
- Dunming Zhu (ORCID: https://orcid.org/0000-0001-8783-5358)
- Xiaohui Yan (ORCID: https://orcid.org/0000-0003-4180-8543)
- Zefei Xu (ORCID: https://orcid.org/0000-0002-3710-3623)
- Qiaqing Wu (ORCID: https://orcid.org/0000-0001-7405-1562)
- Mengting Zhang
- Peiyuan Yao (ORCID: https://orcid.org/0000-0003-4029-5985)
- Yu Li
- Lu Chen
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acs.orglett.6c01337
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin Science and Technology Program