En Route to <i>N</i> -α-Silylated Thioureas via Iridium-Catalyzed C(sp <sup>3</sup> )–H Silylation
)-H bonds in thiourea derivatives using hydrosilanes, affording a broad range of mono- and bis-α-silyl-functionalized thioureas in moderate to excellent yields. The directing effect of the intrinsic thiocarbonyl group was pivotal to this silylation. The synthetic potential was demonstrated by a gram-scale reaction and the derivatization of α-silylated thioureas.
Authors
- Li‐Wen Xu (ORCID: https://orcid.org/0000-0001-5705-0015)
- Lei Yang (ORCID: https://orcid.org/0000-0001-9172-0879)
- Lei Wang
- Wenjie Hu
Institutions
- Hangzhou Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acs.orglett.6c00858
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hangzhou Science and Technology Bureau
- Natural Science Foundation of Zhejiang Province