Evaluating Effective Biomarker Testing for Advanced Non–Small Cell Lung Cancer in US Community Oncology Practices

PURPOSE: . However, the rate of effective testing, defined as the availability of actionable results before treatment initiation, has not been examined in a US community oncology setting in a more contemporary patient sample. This study quantified effective testing rates and patient factors associated with testing. METHODS: This retrospective study included patients with stage IIIB/IIIC/IV NSCLC treated within ONCare Alliance, a network of 30 US community oncology practices. Data collection consisted of patient demographics, disease characteristics, biomarker testing details (order date, test type, assays), and result availability at diagnosis and at the start of systemic therapy. RESULTS: = .003) were more likely to undergo biomarker testing. Only 39.5% (95% CI, 34.0 to 45.3) was tested for all 13 National Comprehensive Cancer Network-recommended biomarkers. CONCLUSION: Although overall testing rates were high, more than 20% of patients lacked timely results to guide initial therapy. This critical gap may limit access to biomarker-directed treatment and highlights the need for streamlined diagnostic workflows and faster turnaround times to ensure optimal, evidence-based care in community oncology.