Early fibrotic niches establish tumour-permissive microenvironments
-inducible human alveolar organoids and early-stage lung adenocarcinoma tissues identifies epithelial-microenvironment communication as a therapeutically actionable vulnerability and suggests that intercepting niche formation may prevent progression to treatment-resistant disease.
Authors
- Bon‐Kyoung Koo (ORCID: https://orcid.org/0000-0002-4134-8033)
- Joo‐Hyeon Lee (ORCID: https://orcid.org/0000-0002-7364-6422)
- Frances J. England (ORCID: https://orcid.org/0000-0003-0821-8015)
- H LEE
- Benjamin David Simons (ORCID: https://orcid.org/0000-0002-3875-7071)
- Robin Lu
- Sagar Varankar (ORCID: https://orcid.org/0000-0002-2923-8616)
- Moo Suk Park (ORCID: https://orcid.org/0000-0003-0820-7615)
- Erik Cardoso (ORCID: https://orcid.org/0000-0001-8302-2341)
- Hyunjin Cho (ORCID: https://orcid.org/0000-0003-1538-9728)
- Jinwook Choi (ORCID: https://orcid.org/0000-0003-3221-0929)
- Natasha Rekhtman
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Yonsei University (KR)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- Severance Hospital (KR)
- The Gurdon Institute (GB)
- Gwangju Institute of Science and Technology (KR)
- Kettering University (US)
- Institute for Basic Science (KR)
- Stem Cell Institute (PA)
Publication Details
- Journal
- Nature
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41586-026-10399-6
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00