Structural Insights Into Man <sub>9</sub> Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR
structure, overcoming the signal overlapping problems found in standard NMR experiments. STD NMR analysis revealed a clear preference for the D1 arm in 2G12 antibody recognition, while the D2 and D3 branches also contributed to binding, albeit with weaker STD effects. This relevant information is fundamental for the design of immunogens to elicit 2G12-like antibodies as vaccine components, since recent studies have found that these "glycoepitopes" are also present in other viruses such as SARS-CoV-2 and certain H3N2 influenza strains.
Authors
- Laura Castañar (ORCID: https://orcid.org/0000-0002-4731-0626)
- Adrián Silva-Díaz
- Paola Oquist-Phillips (ORCID: https://orcid.org/0000-0003-4418-3892)
- Ángeles Canales (ORCID: https://orcid.org/0000-0003-0542-3080)
- Javier Rojo (ORCID: https://orcid.org/0000-0003-3173-3437)
- Noelia Cruz
- Javier Ramos‐Soriano
- Inés Lera‐Lasso
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Investigaciones Químicas (ES)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1002/advs.202600025
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Family Process Institute
- European Science Foundation
- European Regional Development Fund