Engineered human plasma-derived cryogels as a multifunctional scaffold to promote diabetic wound healing

, the scaffold demonstrates potent antioxidant activity and attenuates pro-inflammatory responses in macrophages. In a diabetic rat wound model, the PlasmaMA cryogel significantly accelerated wound closure, enhanced collagen deposition and maturation, and improved functional neovascularization compared to scaffolds derived from bovine or human serum albumin. By converging native bioactivity with engineered material properties, the PlasmaMA cryogel creates a pro-healing microenvironment that actively orchestrates tissue repair. This work establishes a versatile human plasma-derived platform as a promising multifunctional therapy for complex wound healing.