H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses
; however, how plants mitigate this post-hypoxic stress to facilitate submergence recovery has remained unknown. Here we report that ERFVIIs are also important in post-submergence recovery, remaining stable upon reoxygenation through ROS-mediated PCO inhibition. Stabilized ERFVIIs are retained at hypoxia-responsive promoters, becoming repressors of typical hypoxia marker genes but upregulators of genes involved in ROS homeostasis and oxidative stress protection. Our findings suggest that PCOs and ERFVIIs integrate signals from both oxygen and ROS to coordinate ERFVII stability through submergence-induced hypoxia and desubmergence stress to promote plant survival and recovery.
Authors
- Beatrice Giuntoli (ORCID: https://orcid.org/0000-0003-4968-4071)
- Yuming He (ORCID: https://orcid.org/0000-0001-8530-5652)
- William K. Myers (ORCID: https://orcid.org/0000-0001-5935-9112)
- Mikel Lavilla-Puerta (ORCID: https://orcid.org/0000-0001-9920-9020)
- Markus Schwarzländer (ORCID: https://orcid.org/0000-0003-0796-8308)
- Emily Flashman (ORCID: https://orcid.org/0000-0002-4169-4278)
- Francesco Licausi (ORCID: https://orcid.org/0000-0003-4769-441X)
- Sophie Lichtenauer (ORCID: https://orcid.org/0000-0003-4525-6555)
- Laura Dalle Carbonare (ORCID: https://orcid.org/0000-0002-7536-7654)
- Monica Perri (ORCID: https://orcid.org/0000-0001-6955-4691)
- Pedro Barreto (ORCID: https://orcid.org/0000-0002-2702-8084)
- Daai Zhang (ORCID: https://orcid.org/0000-0003-1280-421X)
- Yuri Telara (ORCID: https://orcid.org/0009-0002-8774-6413)
- Salma Akter
- Dona M. Gunawardana
- Vinay Shukla
Institutions
- University of Pisa (IT)
- University of Münster (DE)
- University of Oxford (GB)
- University of Bologna (IT)
Publication Details
- Journal
- Nature
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1038/s41586-026-10366-1
- Citations
- 1
- Primary Topic
- Plant responses to water stress
- Type
- article
- Field-Weighted Citation Impact
- 17.54