Catalyst-Free, Visible-Light-Triggered One-Pot Formation of Imidazole <i>N</i> -Oxide Derivatives in H <sub>2</sub> O/EtOH Medium: Investigation of Their Therapeutic Properties
-oxide derivatives with acceptable to exceptional yields (up to 98%). The usefulness of the method was demonstrated by gram-scale synthesis, which yielded the desired product in 72% yield, and by scale-up experiments that examined yield variance across mmol-scale reactions. Green chemistry parameters were also determined, suggesting that this method generates fewer waste products and is more environmentally friendly. The preliminary biological evaluation of the produced compounds revealed that various derivatives have significant antioxidant, antidiabetic, and anti-inflammatory properties. Furthermore, cytotoxicity investigations against the WRL-68 cell line revealed that certain compounds have low cytotoxicity, indicating possible biological compatibility.
Authors
- Mohabul A. Mondal (ORCID: https://orcid.org/0000-0002-1318-4115)
- Dilip K. Maiti (ORCID: https://orcid.org/0000-0001-8743-2620)
- Hari Sankar Das (ORCID: https://orcid.org/0000-0003-0036-0244)
- Sangita Dey (ORCID: https://orcid.org/0000-0003-3856-7339)
- Gouhar Jahan Ashraf (ORCID: https://orcid.org/0009-0006-8296-6707)
- Anoop Kumar
- Pintu Pratihar
- Manirul Mandal
- Kaberi Sikdar
- Ranabir Sahu
Institutions
- University of Calcutta (IN)
- Jadavpur University (IN)
- North Bengal University (IN)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1021/acsomega.5c13523
- Primary Topic
- Synthesis and Reactions of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- University Grants Commission