Highly Regioselective Ru(II)‐Catalyzed Hydroamination of Ynamides With Phenyl Isocyanates
A novel and efficient method for the synthesis of (Z)‐1‐(1‐(2‐oxooxazolidin‐3‐yl)‐2‐phenylvinyl)−1,3‐diphenylurea derivatives via Ru (II)‐catalyzed hydroamination of ynamides with phenyl isocyanates has been developed. This protocol features excellent regioselectivity with a wide range of substrate scopes of phenyl isocyanates and ynamides. Using this method, highly substituted oxooxazolidinyl phenylvinyl 1,3‐diphenylurea compounds were synthesized in moderate to excellent yields.
Authors
- Shubham Jaiswal (ORCID: https://orcid.org/0009-0006-0123-7810)
- A T Rajesh Kumar
- Narender Tadigoppula (ORCID: https://orcid.org/0009-0009-1616-2008)
Institutions
- Central Drug Research Institute (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2026-04-22
- DOI
- https://doi.org/10.1002/ejoc.70468
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00